The AVAR® line of products provides safe and effective treatment of seborrheic dermatitis (SD), acne vulgaris (AV), and acne rosacea (AR). AVAR® products contain sodium sulfacetamide, a sulfonamide antibiotic.
It is important to note that SD is basically dandruff of the face and body, and can involve the scalp, eyebrows, eyelids, nasolabial folds, ears, upper chest, underarms, under the breasts, and groin. The edges of the eyelids are commonly affected as well, and can cause severe irritation known as blepharitis. SD is often seen in men with beards.
WARNINGS: Although rare, sensitivity to sodium sulfacetamide may occur. Therefore, caution and careful supervision should be observed when prescribing this drug for patients who may be prone to hypersensitivity to topical sulfonamides. Systemic toxic reactions such as agranulocytosis, acute hemolytic anemia, purpura hemorrhagica, drug fever, jaundice and contact dermatitis indicate hypersensitivity to sulfonamides. Particular caution should be employed if areas of denuded or abraded skin are involved.
Sulfonamides are known to cause Stevens-Johnson syndrome in hypersensitive individuals. Stevens-Johnson syndrome also has been reported following the use of sodium sulfacetamide topically. Cases of drug induced systemic lupus erythematosus from topical sulfacetamide also have been reported. In one of these cases, there was a fatal outcome. KEEP OUT OF REACH OF CHILDREN. Sulfonamides have bacteriostatic properties, which means that they prevent bacteria from growing.
AVAR® products also contain sulfur, but in varying degrees. In addition to acting as a drying agent, sulfur acts as a keratolytic, which promotes the shedding of the top layer of skin. AVAR® products are contraindicated in patients who have known hypersensitivity to sulfonamides, sulfur or related compounds. These products should also not be used by patients with kidney disease.